Fda has received a number of inquiries on the safety of phthalates, which are used in a variety of cosmetics as well as other consumer products. Regulatory information sara 302 components no chemicals in this material are subject to the reporting requirements of sara title iii, section 302. Exposure to high aerosol concentrations may result in respiratory tract irritation and mild central. Dbp is also listed in the list of 66 potentially endocrine substances with classification of high exposure concern. Linking to a nonfederal website does not constitute an endorsement by cdc or any of its employees of the sponsors or the information and products presented on the website. Material safety data sheet dibutyl sebacate, dbs march 24, 2008 page 3 of 3 section ix. Slightly hazardous in case of skin contact irritant, permeator, of ingestion, of inhalation. Identification product name dibutyl phthalate cat no. Dibutyl phthalate is used to help make plastics soft and flexible. Diisononyl phthalate please ensure that this msds is given to, and explained to people using this product. Links with this icon indicate that you are leaving the cdc website the centers for disease control and prevention cdc cannot attest to the accuracy of a nonfederal website. Observe all federal, state and local regulations when storing or disposing of this substance. Dibutyl phthalate safety msds data page two of two toxicology dibutyl phthalate dbp does not readily form vapour and inhalation exposures are unlikely to occur unless dbp is misted or heated. Its structural formula is c 6 h 4 cooch 2 chch 3 2 2 dibp is an odorless plasticizer and has excellent heat and light stability.
In the present study, we found that treatment of embryos with 103 m mbp impaired developmental competency, whereas exposure to 104m mbp delayed the progression of preimplantation embryos to the blastocyst stage. Sara 3 components the following components are subject to reporting levels established by sara title iii, section 3. Dibutyl phthalate dbp, a widely used phthalate, is known to cause many serious diseases, especially in the reproductive system. Page 17 safety data sheet according to 19072006ec, article 31 printing date 07.
Rinse mouth immediately and then drink plenty of water, seek medical attention. Wash affected eyes for at least 15 minutes under running water with eyelids held open. It has the ability to leach and evaporate into the environment while using or disposing of these products. Dbp is a substance that is used as a plasticiser to make pvc plastic soft and flexible. Safety data sheet creation date 03dec2010 revision date 17jan2018 revision number 3 1. Dibutyl phthalate 99% nbutyl phthalate sigmaaldrich.
Based on the very limited data on concentrations of dibutyl phthalate in various environmental media ambient air, indoor air, drinking water, food, and soil, the average daily intakes of dibutyl phthalate for different age groups in the general population have been estimated. Dibutyl phthalate included in the candidate list of substances of very high concern. It appears to have relatively low acute shortterm and chronic longterm toxicity. Our msds database is an easy to use, do it yourself tool, and best of all. However, little is known about the effects of its metabolite, mononbutyl phthalate mbp, on preimplantation embryo development. No information is available regarding the effects in humans from inhalation or oral exposure to dibutyl phthalate, and only. Dibutyl phthalate definition is a colorless oily ester c16h22o4 used chiefly as a solvent, plasticizer, and insect repellent. Therefore, studies are being conducted to assess its toxic and apoptotic effects.
Chromatography, flame ionization detector, gas chromatography, purification. Once this active compound was recovered by ethyl acetate from the. Plasticization of vinyl resins and other kinds of polymers in production of cable flexible. Dibutyl phthalate is a phthalate ester that is the diester obtained by the formal condensation of the carboxy groups of phthalic acid with two molecules of butan1ol. Special precautions precautions to be taken in handling and storage store away from incompatible substances.
Dibutyl phthalate united states environmental protection. Inadvertent inhalation of vomited material may seriously damage the lungs. Butyl benzyl phthalate first draft prepared by ms m. Meek, environmental health directorate, health canada please note that the layout and pagination of this pdf file are not identical to those of th printed cicad published under the joint sponsorship of the united nations environment programme, the. Recent studies in test animals suggest that dibutyl phthalate may have adverse effects on the unborn child when the mother is exposed during pregnancy. The main sources of information for this fact sheet are epas integrated risk information. Absorption of diethyl phthalate and three other phthalates dimethyl, dibutyl, and di2ethylhexyl was measured using human epidermal skin obtained from the abdominal skin of 11 cadavers mostly females 55 years of age or older and subcutaneous fat removed in vitro. The revised idlh for dibutyl phthalate is 4,000 mgm 3 based on acute inhalation toxicity data in animals izmerov et al. Introduction entries 51 and 52 of annex xvii to reach include the restrictions on the placing on the market and use of certain phthalates in toys and childcare articles, as initially. Although used extensively as a plasticiser, it is a ubiquitous environmental contaminant that poses a risk to humans. Read the product manufacturers material safety data. Please ensure that this msds is given to, and explained to people using this product.
Pdf dibutyl phthalate, the bioactive compound produced. Diisobutyl phthalate not established not established exposure controls. Diisobutyl phthalate dibp is prepared by esterification process of isobutanol and phthalic anhydride. Dibutyl phthalate definition of dibutyl phthalate by. Dibutyl phthalate dbp is most commonly used as a plasticizer in a variety of household products. Uses advised against details of the supplier of the safety data sheet emergency. Other companies are charging thousands of dollars to set up accounts and give you access to their msds online database. Other companies are charging thousands of dollars to set up. Show this safety data sheet to the doctor in attendance. It is used in shower curtains, raincoats, food wraps, bowls, car interiors, vinyl fabrics, floor tiles, and other products. This product contains a chemical known to the state of california to cause birth defects or other reproductive harm.
Your new online msds binder is a place for you to store the material safety data sheets you need to deploy. Dibutyl phthalate is a phthalate ester with extensive use in industry in such products as plastic pvc piping, various varnishes and lacquers, safety glass, nail polishes, paper coatings, dental materials, pharmaceuticals, and plastic food wrap. Dinbutyl phthalate page 2 of 6 determining your exposure f read the product manufacturers material safety data sheet msds and the label to determine product ingredients and important safety and health information. The best protection is to enclose operations andor provide local exhaust ventilation at the site of chemical release. Cdc niosh pocket guide to chemical hazards dibutyl. Please see the following for information about the library and its accompanying search program. Sigmaaldrich offers a number of dibutyl phthalate products.
Dibutyl phathalate included in the candidate list of substance of very high concern svhc according to regulation ec no. It was found that the bioactive compound, dibutyl phthalate, was produced by a new soil isolate streptomyces albidoflavus 321. Dibutyl phthalate is used in making flexible plastics that are found in a variety of consumer products. It is the lowest cost plasticizer for cellulose nitrate. Dibp has lower density and freezing point than the related compound dibutyl phthalate dbp. It is recommended safety shower and eye bath available near work side. Dibutyl phthalate revision date 17jan2018 component ld50 oral ld50 dermal lc50 inhalation dibutyl phthalate ld50 7499 mgkg rat 20000 mgkg rabbit lc50 15. Dibutyl phthalate safety msds data valetime group limited. This msds has been prepared in compliance with controlled product regulations except for the use of the 16. All mass spectra in this site plus many more are available from the nistepanih mass spectral library. Toxicity effects, acute exposure skin contact little to no effect skin absorption not absorbed through the skin. Dibutyl phathalate included in the candidate list of substance of very. What health effects can dbp cause in laboratory animals. Due to its low volatility, this concentration could only be reached at elevated temperatures or if the liquid droplets become airborne as.
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